THE STATE OF THE ANTIMICROBIAL SYSTEM OF THE ORAL CAVITY IN PATIENTS WITH INSULIN RESISTANCE

Abstract

The aim of this study was to evaluate the antimicrobial activity of oral fluid peptides in patients with insulin resistance. The objects of the study were 32 patients who were divided into the main study group and the control group. Of these, 18 patients were included in the main group at the stages of treatment for insulin resistance, in which a high level of C-peptide in the blood was detected by enzyme immunoassay. In the oral fluid, the amount of the antimicrobial peptide, cathelicidin LL-37, alpha-defensin 1-3, was assessed by enzyme immunoassay. In studies in the oral fluid of patients with IR, instead of a pronounced increase in the antimicrobial peptide, a decrease in its concentration was revealed, which requires additional studies.