AN INTERACTION OF ENDOGENOUS INTOXICATION WITH DISTURBANCE OF FUNCTIONAL AND METABOLIC FEATURES OF LIVER IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA

Abstract

Endogenous intoxication is primarily related to the accumulation of toxic metabolites due to a decrease of pharmacometabolizing function of the liver. The level of oligopeptides characterizes the severity of intoxication. Information on the role of the liver in the development of intoxication in chronic myeloleukemia (CML) is absent. The aim of the study was to determine the content of oligopeptides in blood serum and its relation to structural functional parameters of the liver in CML. We examined 98 patients aged 18-63 years with CML. Nine eight patients aged 18-63, of them 40 in chronic, 44 in acceleration and 14 in blastic crisis stages were observed. The diagnosis of hemoblastosis was established in cooperation with hematologists according to conventional criteria based on the blood and bone marrow tests. Combined basis therapy including glivec, hydrea and hormonal preparations was conducted in all the cases. The condition of the liver was assessed by clinical, instrumental and biochemical investigations. The content of oligopeptides was determined by spectrophotometry. The same studies were performed in 16 healthy subjects (control). Patients with CML presented with endogenous intoxication characterized by an accumulation of oligopeptides especially in the chronic stage. In acceleration and blastic crisis stage oligopeptides were probably stored in microcirculatory bed of tissues. Accumulation of oligopeptides was caused by structural-metabolic disorders of the liver especially in the blastic crisis stage with high parameters of the cytolitic syndrome. More pronounced liver disorders were observed in gormone therapy compared to use of glivec and hydrea.